Keep an eye on Carefully (1)pentobarbital will lower the level or impact of osilodrostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the extent or impact of acalabrutinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will minimize the extent or impact of cortisone by